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Company ReportsKaryopharm Therapeutics

Karyopharm Therapeutics(KPTI)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Xpovio	Selinexor	2019-07-03	2032-2035	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

neoplasm metastasis

,

biphenotypic leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

renal cell carcinoma

,

fallopian tube neoplasms

,

,

cutaneous malignant melanoma

,

rectal neoplasms

,

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

chromosome aberrations

,

b-cell chronic lymphocytic leukemia

,

prolymphocytic leukemia

,

lymphoid leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

,

endometrial stromal sarcoma

,

hodgkin disease

,

brain neoplasms

,

nervous system neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hepatocellular carcinoma

,

liver neoplasms

,

phenylketonurias

,

hematopoietic stem cell transplantation

,

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

non-hodgkin lymphoma

,

myelodysplastic syndromes

,

,

,

ovarian neoplasms

,

neurofibrosarcoma

,

extranodal nk-t-cell lymphoma

,

central nervous system neoplasms

,

,

,

breast neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

,

,

colorectal neoplasms

,

nerve sheath neoplasms

,

,

small cell lung carcinoma

,

thrombocytopenia

,

squamous cell neoplasms

,

alveolar soft part sarcoma

,

,

pancreatic ductal carcinoma

,

prostatic neoplasms

,

coronavirus infections

,

,

glandular and epithelial neoplasms

,

thymus neoplasms

,

,

,

drug-related side effects and adverse reactions

,

gastrointestinal stromal tumors

,

maximum tolerated dose

,

recreational drug use

,

pancreatic neoplasms

,

acinar cell carcinoma

,

squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

waldenstrom macroglobulinemia

,

urologic neoplasms

,

transitional cell carcinoma

,

,

communicable diseases

,

,

,

,

t-cell lymphoma cutaneous

,

neuroendocrine carcinoma

,

uterine cervical neoplasms

,

smoldering multiple myeloma

,

residual neoplasm

,

ovarian epithelial carcinoma

,

,

,

clear cell sarcoma

,

,

solitary fibrous tumors

,

hemangiosarcoma

,

epithelioid hemangioendothelioma

,

myxoid liposarcoma

,

benign fibrous histiocytoma

,

vascular neoplasms

,

,

disorders of sex development

,

dermatofibrosarcoma

,

adipose tissue neoplasms

,

smooth muscle tumor

,

plasma cell granuloma

,

granular cell tumor

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

multiple myeloma

,

plasma cell neoplasms

,

myeloid leukemia acute

,

,

,

,

myeloid leukemia

,

primary myelofibrosis

,

endometrial neoplasms

,

,

,

myeloproliferative disorders

,

,

uterine neoplasms

,

neoplasms by site

,

uterine diseases

,

genital diseases

,

epstein-barr virus infections

,

hemophagocytic lymphohistiocytosis

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

mantle-cell lymphoma

,

salivary gland neoplasms

,

,

myeloid sarcoma

multiple myeloma

,

plasma cell neoplasms

,

multiple myeloma

,

plasma cell neoplasms

,

primary myelofibrosis

,

,

small cell lung carcinoma

,

migraine disorders

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

burkitt lymphoma

psoriatic arthritis

,

,

,

intestinal volvulus

,

large b-cell lymphoma diffuse

,

b-cell chronic lymphocytic leukemia

,

non-hodgkin lymphoma

,

,

follicular lymphoma

,

,

lymphoid leukemia

,

,

,

,

,

,

,

,

large-cell lymphoma anaplastic

,

clear cell sarcoma

,

healthy volunteers/patients

,

neoplasms by histologic type

,

neoplasms by site

,

nervous system neoplasms

,

aids-related lymphoma

,

optic nerve glioma

,

primitive neuroectodermal tumors peripheral

,

leukemia myeloid chronic atypical bcr-abl negative

,

immunoblastic lymphadenopathy

,

hairy cell leukemia

,

,

eyelid diseases

,

basal cell carcinoma

,

merkel cell carcinoma

,

basal cell neoplasms

,

human influenza

,

brain stem neoplasms

,

cerebrotendinous xanthomatosis

,

adenocarcinoma of lung

,

,

mycobacterium avium-intracellulare infection

,

cognitive dysfunction

,

,

,

myasthenia gravis

,

conjunctival neoplasms

,

alveolar soft part sarcoma

,

salivary gland neoplasms

,

testicular neoplasms

,

medullary carcinoma

,

thrombocytopenia

,

paroxysmal hemoglobinuria

,

aids-related complex

,

,

drug-related side effects and adverse reactions

,

pharmacokinetics

,

oligodendroglioma

,

pseudomyxoma peritonei

,

colorectal neoplasms

,

ovarian neoplasms

,

b-cell chronic lymphocytic leukemia

,

mantle-cell lymphoma

,

myeloproliferative disorders

,

fallopian tube neoplasms

,

,

myelomonocytic leukemia chronic

,

,

small cell lung carcinoma

,

male breast neoplasms

,

,

kidney neoplasms

,

aplastic anemia

,

t-cell lymphoma peripheral

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

myelomonocytic leukemia juvenile

,

ovarian epithelial carcinoma

,

central nervous system neoplasms

,

,

t-cell lymphoma

,

,

cutaneous malignant melanoma

,

myeloid leukemia accelerated phase

,

respiratory distress syndrome

,

communicable diseases

,

,

colonic neoplasms

,

waldenstrom macroglobulinemia

,

large-cell lymphoma immunoblastic

,

stem cell transplantation

,

refractory anemia

,

myelodysplastic-myeloproliferative diseases

,

,

alzheimer disease

,

uveal neoplasms

,

,

squamous cell carcinoma of head and neck

,

cholangiocarcinoma

,

rectal neoplasms

,

,

rheumatoid arthritis

,

,

endometrial neoplasms

,

b-cell lymphoma marginal zone

,

primary myelofibrosis

,

t-cell lymphoma cutaneous

,

,

castration-resistant prostatic neoplasms

,

peripheral arterial disease

,

ductal carcinoma breast

,

intraductal carcinoma noninfiltrating

,

plasma cell leukemia

,

,

eyelid neoplasms

,

,

nasopharyngeal carcinoma

,

,

,

immunoglobulin light-chain amyloidosis

,

diffuse intrinsic pontine glioma

,

transitional cell carcinoma

,

esophageal neoplasms

,

interdigitating dendritic cell sarcoma

,

sezary syndrome

,

mycosis fungoides

,

kidney transplantation

,

malignant mesothelioma

,

fanconi syndrome

,

glandular and epithelial neoplasms

,

endometrioid carcinoma

,

,

,

peritoneal neoplasms

,

mycobacterium infections

,

bronchiolitis obliterans syndrome

,

severe acute respiratory syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

,

cystic fibrosis

,

pancreatic ductal carcinoma

,

gallbladder neoplasms

,

hematopoietic stem cell transplantation

,

meningeal carcinomatosis

,

myeloid sarcoma

,

branchio-oto-renal syndrome

,

hypereosinophilic syndrome

,

inflammatory breast neoplasms

,

ganglioneuroblastoma

,

residual neoplasm

,

nasopharyngeal neoplasms

,

gastrointestinal neoplasms

,

neuroendocrine tumors

,

neuroendocrine carcinoma

,

islet cell carcinoma

,

urethral neoplasms

,

ureteral neoplasms

,

invasive hydatidiform mole

,

esophageal squamous cell carcinoma

,

sickle cell anemia

,

renal insufficiency

,

immunologic deficiency syndromes

,

,

pulmonary hypertension

,

interstitial lung diseases

,

lymphoproliferative disorders

,

extranodal nk-t-cell lymphoma

,

prolymphocytic leukemia

,

second primary neoplasms

,

,

bone marrow diseases

,

thymus neoplasms

,

biliary tract neoplasms

,

,

mucinous cystadenocarcinoma

,

serous cystadenocarcinoma

,

cystadenocarcinoma

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

animal mammary neoplasms

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

systemic lupus erythematosus

,

severe acute respiratory syndrome-related coronavirus

,

,

kidney diseases

,

urogenital neoplasms

,

prostatic diseases

,

male genital neoplasms

,

critical illness

,

immunosuppression therapy

,

,

,

nontuberculous mycobacterium infections

,

vascular diseases

,

atherosclerosis

,

respiratory aspiration

,

intermittent claudication

,

pneumococcal pneumonia

,

,

bile duct neoplasms

,

intestinal neoplasms

,

,

peripheral blood stem cell transplantation

,

,

,

meningeal neoplasms

,

soft tissue neoplasms

,

philadelphia chromosome

,

,

,

myelodysplastic syndromes

,

breast neoplasms

,

myeloid leukemia

,

plasma cell neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

,

neoplasm metastasis

,

,

large b-cell lymphoma diffuse

,

,

lymphoid leukemia

,

,

non-small-cell lung carcinoma

,

,

burkitt lymphoma

,

pancreatic neoplasms

,

,

,

follicular lymphoma

,

pulmonary alveolar proteinosis

,

hematologic neoplasms

,

b-cell lymphoma

,

brain neoplasms

,

,

renal cell carcinoma

,

,

graft vs host disease

,

rhabdomyosarcoma

,

germ cell and embryonal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

medulloblastoma

,

acquired immunodeficiency syndrome

,

myeloid leukemia chronic-phase

,

,

refractory anemia with excess of blasts

,

triple negative breast neoplasms

,

congenital abnormalities

,

,

myelomonocytic leukemia acute

,

biphenotypic leukemia acute

,

monocytic leukemia acute

,

chemotherapy-induced febrile neutropenia

,

,

urinary bladder neoplasms

,

giant cell tumor of tendon sheath

,

stomach neoplasms

,

,

hematologic diseases

,

,

squamous cell carcinoma

,

pigmented villonodular synovitis

,

,

pathologic complete response

,

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

systemic scleroderma

,

diffuse scleroderma

,

,

squamous cell neoplasms

,

head and neck neoplasms

,

megakaryoblastic leukemia acute

,

erythroblastic leukemia acute

,

cytomegalovirus retinitis

,

,

,

giant cell tumors

,

uterine cervical neoplasms

,

hematopoietic stem cell mobilization

,

induction chemotherapy

,

t-cell leukemia

,

coronavirus infections

,

choriocarcinoma

,

,

endodermal sinus tumor

,

,

autoimmune diseases

,

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

cutaneous leishmaniasis

,

,

,

myeloid leukemia acute

,

,

multiple myeloma

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

prostatic neoplasms

,

non-hodgkin lymphoma

,

,

,

,

chronic hepatitis b

,

,

,

multiple organ failure

,

wounds and injuries

,

,

,

abnormal karyotype

,

primitive neuroectodermal tumors

,

retinal neoplasms

,

neuroectodermal tumors

,

phenylketonurias

,

liver cirrhosis

,

uterine neoplasms

,

,

cytokine release syndrome

,

normal pressure hydrocephalus

,

,

diabetes mellitus

,

frontotemporal dementia

,

neuroinflammatory diseases

,

corticobasal degeneration

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

periodontal diseases

,

,

,

,

discoid lupus erythematosus

,

systemic lupus erythematosus

,

cutaneous lupus erythematosus

,

multiple myeloma

,

plasma cell neoplasms

,

healthy volunteers/patients

,

Calcium dobesilate

healthy volunteers/patients

,

,

hairy cell leukemia

,

,

vascular diseases

,

castration-resistant prostatic neoplasms

,

endometrioid carcinoma

,

sickle cell anemia

,

cesarean section

,

sleep deprivation

,

oligodendroglioma

,

,

beta-thalassemia

,

,

hemoglobinopathies

,

aortic coarctation

,

systemic mastocytosis

,

,

,

,

premature birth

,

autonomic nervous system diseases

,

stomach neoplasms

,

,

lacrimal apparatus diseases

,

,

neuroepithelial neoplasms

,

liver neoplasms

,

medulloblastoma

,

,

,

,

spinal cord neoplasms

,

large granular lymphocytic leukemia

,

pituitary neoplasms

,

choroid plexus neoplasms

,

craniopharyngioma

,

primitive neuroectodermal tumors

,

choriocarcinoma

,

,

,

,

endodermal sinus tumor

,

neuroectodermal tumors

,

,

pituitary diseases

,

phenylketonurias

,

chromophobe adenoma

,

basophil adenoma

,

acidophil adenoma

,

,

solitary pulmonary nodule

,

lymphoproliferative disorders

,

blood coagulation disorders

,

hemostatic disorders

,

paraproteinemias

,

immunoproliferative disorders

,

hemorrhagic disorders

,

malignant mesothelioma

,

,

retinal telangiectasis

,

retinal perforations

,

,

triple negative breast neoplasms

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

b-cell lymphoma marginal zone

,

,

hematologic neoplasms

,

,

,

b-cell chronic lymphocytic leukemia

,

t-cell lymphoma cutaneous

,

plasma cell leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

ovarian neoplasms

,

t-cell leukemia

,

large-cell lymphoma anaplastic

,

adult t-cell leukemia-lymphoma

,

,

squamous cell carcinoma of head and neck

,

germ cell and embryonal neoplasms

,

sezary syndrome

,

myeloid leukemia chronic-phase

,

mycosis fungoides

,

large-cell lymphoma immunoblastic

,

,

blastic plasmacytoid dendritic cell neoplasm

,

intraocular lymphoma

,

lymphomatoid granulomatosis

,

squamous cell carcinoma

,

myeloid leukemia accelerated phase

,

testicular neoplasms

,

rectal neoplasms

,

oropharyngeal neoplasms

,

uveal neoplasms

,

,

pancreatic neoplasms

,

hemophagocytic lymphohistiocytosis

,

squamous cell neoplasms

,

cholangiocarcinoma

,

,

esophageal neoplasms

,

vitreous hemorrhage

,

extranodal nk-t-cell lymphoma

,

immunoblastic lymphadenopathy

,

,

nervous system neoplasms

,

residual neoplasm

,

,

uterine cervical neoplasms

,

b-cell leukemia

,

radiation injuries

,

wet macular degeneration

,

,

endocrine gland neoplasms

,

pelvic organ prolapse

,

clonal hematopoiesis

,

colonic neoplasms

,

bone marrow transplantation

,

homologous transplantation

,

autologous transplantation

,

hepatocellular carcinoma

,

biliary tract neoplasms

,

,

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

epstein-barr virus infections

,

,

oral lichen planus

,

,

fuchs' endothelial dystrophy

,

hereditary corneal dystrophies

,

retinitis pigmentosa

,

,

,

pathologic complete response

,

,

retinal neovascularization

,

plasmablastic lymphoma

,

,

airway obstruction

,

,

,

small cell carcinoma

,

small cell lung carcinoma

,

proteostasis deficiencies

,

retinal degeneration

,

,

cytokine release syndrome

,

,

mucinous adenocarcinoma

,

carbon monoxide poisoning

,

sleep wake disorders

,

nephrolithiasis

,

,

,

mandibular fractures

,

,

post-acute covid-19 syndrome

,

non-hodgkin lymphoma

,

burkitt lymphoma

,

immunoglobulin light-chain amyloidosis

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

large b-cell lymphoma diffuse

,

hodgkin disease

,

,

b-cell lymphoma

,

myeloid leukemia acute

,

smoldering multiple myeloma

,

philadelphia chromosome

,

brain neoplasms

,

follicular lymphoma

,

neoplasm metastasis

,

myelodysplastic syndromes

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

myeloid leukemia

,

hypersensitivity

,

central nervous system neoplasms

,

,

,

myelomonocytic leukemia chronic

,

respiratory distress syndrome

,

ataxia telangiectasia

,

,

,

,

myelomonocytic leukemia acute

,

hematologic diseases

,

,

,

inborn genetic diseases

,

,

,

,

,

male breast neoplasms

,

congenital abnormalities

,

myelomonocytic leukemia juvenile

,

rotator cuff injuries

,

,

human influenza

,

viral pneumonia

,

newborn respiratory distress syndrome

,

nervous system diseases

,

,

,

congenital adrenal hyperplasia

,

,

,

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

erythroblastic leukemia acute

,

,

uterine hemorrhage

,

promyelocytic leukemia acute

,

inflammatory breast neoplasms

,

disease progression

,

coronavirus infections

,

wounds and injuries

,

traumatic brain injuries

,

,

cerebellar ataxia

,

substance-related disorders

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

ureteral neoplasms

,

,

,

hyperbilirubinemia

,

,

conduction anesthesia

,

replacement arthroplasty hip

,

thrombocytopenic purpura idiopathic

,

,

,

adrenogenital syndrome

,

adrenocortical hyperfunction

,

,

,

,

ocular motility disorders

,

,

opsoclonus-myoclonus syndrome

,

,

,

bone marrow diseases

,

acquired immunodeficiency syndrome

,

immune reconstitution inflammatory syndrome

,

,

allergic rhinitis

,

allergic rhinitis perennial

,

,

,

,

,

basophilic leukemia acute

,

eosinophilic leukemia acute

,

refractory anemia with excess of blasts

,

refractory anemia

,

acute lung injury

,

breast carcinoma in situ

,

,

,

spinal diseases

,

spinal dysraphism

,

,

acanthamoeba keratitis

,

agranulocytosis

,

feeding behavior

,

,

keratoconjunctivitis

,

bronchiolitis obliterans syndrome

,

,

multiple myeloma

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

plasma cell neoplasms

,

,

,

lymphoid leukemia

,

postoperative pain

,

,

,

,

,

,

retinal vein occlusion

,

,

postoperative nausea and vomiting

,

,

,

breast neoplasms

,

dry eye syndromes

,

diabetic retinopathy

,

biphenotypic leukemia acute

,

prostatic neoplasms

,

diabetes mellitus

,

,

,

,

t-cell lymphoma

,

non-small-cell lung carcinoma

,

replacement arthroplasty knee

,

epiretinal membrane

,

,

retinal diseases

,

,

t-cell lymphoma peripheral

,

macular degeneration

,

vision disorders

,

cataract extraction

,

,

,

,

,

renal insufficiency

,

capsule opacification

,

anesthesia and analgesia

,

pain management

,

migraine disorders

,

knee osteoarthritis

,

shoulder injuries

,

,

retinal detachment

,

,

posterior uveitis

,

,

,

allergic conjunctivitis

,

drug-related side effects and adverse reactions

,

respiratory sounds

,

local anesthesia

,

brachial plexus block

,

spinal anesthesia

,

hip osteoarthritis

,

,

,

,

,

patient preference

,

respiratory insufficiency

,

intervertebral disc displacement

,

,

,

anterior uveitis

,

,

,

obstructive sleep apnea

,

,

trigger finger disorder

,

,

sensorineural hearing loss

,

,

,

type 2 diabetes mellitus

,

carpal tunnel syndrome

,

gastrointestinal neoplasms

,

,

,

,

colorectal neoplasms

,

,

,

shoulder impingement syndrome

,

,

,

intravenous substance abuse

,

spinal stenosis

,

penetrating keratoplasty

,

,

vitreoretinal surgery

,

,

refractive surgical procedures

,

,

peripheral arterial disease

,

peripheral vascular diseases

,

postoperative complications

,

endophthalmitis

,

pathologic constriction

,

subdural hematoma chronic

,

postoperative cognitive complications

,

cognitive dysfunction

,

head and neck neoplasms

,

,

,

intermediate uveitis

,

,

descemet stripping endothelial keratoplasty

,

,

femoral neck fractures

,

,

,

anterior cruciate ligament injuries

,

,

,

,

,

opioid-related disorders

,

urethral stricture

,

gastrointestinal diseases

,

inflammatory bowel diseases

,

digestive system diseases

,

intestinal diseases

,

ambulatory surgical procedures

,

,

ankle fractures

,

graft vs host disease

,

,

pharmacokinetics

,

meibomian gland dysfunction

,

,

treatment outcome

,

,

,

corneal transplantation

,

intraocular pressure

,

viral bronchiolitis

,

temporomandibular joint disorders

,

,

orthopedic procedures

,

sleep apnea syndromes

,

corneal endothelial cell loss

,

,

,

,

,

status asthmaticus

,

meningeal tuberculosis

,

,

bites and stings

,

dental deposits

,

,

femoral fractures

,

,

,

sjogren's syndrome

,

patient-controlled analgesia

,

sudden hearing loss

,

chronic renal insufficiency

,

chronic kidney failure

,

,

diabetic angiopathies

,

,

,

,

foot deformities

,

,

,

dupuytren contracture

,

,

radius fractures

,

fracture fixation

,

elbow tendinopathy

,

wrist fractures

,

,

water intoxication

,

,

venous insufficiency

,

premature rupture fetal membranes

,

,

,

myeloproliferative disorders

,

deglutition disorders

,

,

thyroid diseases

,

dental pulp necrosis

,

,

,

digestive system neoplasms

,

,

mucinous cystadenocarcinoma

,

serous cystadenocarcinoma

,

fallopian tube neoplasms

,

cystadenocarcinoma

,

myelodysplastic-myeloproliferative diseases

,

trophoblastic neoplasms

,

primary myelofibrosis

,

leukemia myeloid chronic atypical bcr-abl negative

,

ovarian epithelial carcinoma

,

neutrophilic leukemia chronic

,

,

,

ureterolithiasis

,

hypertrophic cicatrix

,

,

,

,

,

patient reported outcome measures

,

patient satisfaction

,

,

intractable pain

,

pituitary acth hypersecretion

,

,

hyaline membrane disease

,

chronic urticaria

,

,

trigeminal neuralgia

,

,

dentin sensitivity

,

,

,

,

,

,

thoracic surgical procedures

,

,

infectious skin diseases

,

soft tissue infections

,

,

,

,

transient tachypnea of the newborn

,

thyroid neoplasms

,

vocal cord paralysis

,

postoperative hemorrhage

,

,

chronic obstructive pulmonary disease

,

parathyroid diseases

,

,

biological availability

,

pruritus vulvae

,

intranasal administration

,

therapeutic equivalency

,

,

median neuropathy

,

,

,

,

urinary retention

,

orbital cellulitis

myeloproliferative disorders

,

primary myelofibrosis

,

myelodysplastic-myeloproliferative diseases

,

lipid metabolism disorders

,

hypertriglyceridemia

,

cardiovascular diseases

,

follicular lymphoma

,

huntington disease

,

colonic neoplasms

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

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