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Company ReportsKaryopharm Therapeutics

Karyopharm Therapeutics(KPTI)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Xpovio	Selinexor	2019-07-03	2032-2035	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

neoplasm metastasis

,

biphenotypic leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

lymphoid leukemia

,

renal cell carcinoma

,

fallopian tube neoplasms

,

,

cutaneous malignant melanoma

,

rectal neoplasms

,

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

chromosome aberrations

,

b-cell chronic lymphocytic leukemia

,

prolymphocytic leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

endometrial stromal sarcoma

,

hodgkin disease

,

brain neoplasms

,

nervous system neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hepatocellular carcinoma

,

liver neoplasms

,

phenylketonurias

,

hematopoietic stem cell transplantation

,

,

non-hodgkin lymphoma

,

t-cell lymphoma

,

,

t-cell lymphoma peripheral

,

myelodysplastic syndromes

,

ovarian neoplasms

,

,

,

breast neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

,

,

colorectal neoplasms

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

small cell lung carcinoma

,

central nervous system neoplasms

,

squamous cell neoplasms

,

alveolar soft part sarcoma

,

,

pancreatic ductal carcinoma

,

prostatic neoplasms

,

mantle-cell lymphoma

,

coronavirus infections

,

,

glandular and epithelial neoplasms

,

thymus neoplasms

,

,

thrombocytopenia

,

,

drug-related side effects and adverse reactions

,

gastrointestinal stromal tumors

,

maximum tolerated dose

,

recreational drug use

,

pancreatic neoplasms

,

acinar cell carcinoma

,

essential thrombocythemia

,

polycythemia vera

,

,

,

squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

waldenstrom macroglobulinemia

,

urologic neoplasms

,

transitional cell carcinoma

,

,

communicable diseases

,

,

,

,

t-cell lymphoma cutaneous

,

neuroendocrine carcinoma

,

uterine cervical neoplasms

,

diffuse intrinsic pontine glioma

,

smoldering multiple myeloma

,

residual neoplasm

,

ovarian epithelial carcinoma

,

,

,

,

hemangiosarcoma

,

benign fibrous histiocytoma

,

,

extranodal nk-t-cell lymphoma

,

ductal carcinoma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

multiple myeloma

,

plasma cell neoplasms

,

myeloid leukemia acute

,

,

,

,

myeloid leukemia

,

,

primary myelofibrosis

,

endometrial neoplasms

,

,

,

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

salivary gland neoplasms

multiple myeloma

,

plasma cell neoplasms

,

,

large b-cell lymphoma diffuse

mantle-cell lymphoma

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

b-cell lymphoma

,

large b-cell lymphoma diffuse

,

b-cell chronic lymphocytic leukemia

,

,

,

lymphoid leukemia

,

non-hodgkin lymphoma

,

follicular lymphoma

breast neoplasms

,

triple negative breast neoplasms

,

,

cytomegalovirus retinitis

,

Aglatimagene besadenovec

breast neoplasms

,

ovarian neoplasms

,

non-small-cell lung carcinoma

,

stomach neoplasms

,

head and neck neoplasms

,

esophageal neoplasms

,

,

urinary bladder neoplasms

,

small cell lung carcinoma

,

endophthalmitis

,

lacrimal apparatus diseases

,

,

,

prostatic hyperplasia

,

,

overactive urinary bladder

,

prostatic neoplasms

hairy cell leukemia

,

,

coronary artery disease

,

rheumatoid arthritis

,

,

aids-related complex

,

neoplasms by histologic type

,

,

,

juvenile arthritis

,

,

,

peripheral vascular diseases

,

basal cell carcinoma

,

adenoid cystic carcinoma

,

inverted papilloma

,

verrucous carcinoma

,

mucoepidermoid carcinoma

,

connective and soft tissue neoplasms

,

,

neuroepithelial neoplasms

,

atherosclerosis

,

communicable diseases

,

,

,

craniopharyngioma

,

subependymal glioma

,

clear cell sarcoma

,

monoclonal gammopathy of undetermined significance

,

,

muscular diseases

,

synovial sarcoma

,

mitochondrial diseases

,

,

hidradenitis suppurativa

,

,

cytomegalovirus

,

stem cell research

,

musculoskeletal diseases

,

peripheral arterial disease

,

muscular dystrophies

,

second primary neoplasms

,

,

neurologic manifestations

,

mental disorders

,

dermatomyositis

,

myasthenia gravis

,

muscle weakness

,

optic nerve diseases

,

optic nerve injuries

,

blood platelet disorders

,

pancreatic neoplasms

,

,

,

,

primitive neuroectodermal tumors peripheral

,

fallopian tube neoplasms

,

t-cell lymphoma peripheral

,

colorectal neoplasms

,

,

,

oligodendroglioma

,

prolymphocytic leukemia

,

hematologic diseases

,

t-cell lymphoma

,

immunoblastic lymphadenopathy

,

leukemia myeloid chronic atypical bcr-abl negative

,

lymphoproliferative disorders

,

bone marrow failure disorders

,

,

liver neoplasms

,

ureteral neoplasms

,

,

,

intraocular lymphoma

,

eyelid neoplasms

,

,

acquired immunodeficiency syndrome

,

thrombocytopenia

,

systemic lupus erythematosus

,

aids-related lymphoma

,

fanconi syndrome

,

,

promyelocytic leukemia acute

,

,

plasma cell leukemia

,

optic nerve glioma

,

paroxysmal hemoglobinuria

,

type 1 diabetes mellitus

,

stem cell transplantation

,

beta-thalassemia

,

ischemic stroke

,

dilated cardiomyopathy

,

large granular lymphocytic leukemia

,

philadelphia chromosome

,

lymphomatoid granulomatosis

,

colonic neoplasms

,

squamous cell neoplasms

,

squamous cell carcinoma

,

precancerous conditions

,

extranodal nk-t-cell lymphoma

,

,

essential thrombocythemia

,

chronic limb-threatening ischemia

,

,

myeloid sarcoma

,

paraproteinemias

,

rectal neoplasms

,

embryonal carcinoma

,

salivary gland neoplasms

,

olfactory esthesioneuroblastoma

,

intestinal neoplasms

,

,

nasopharyngeal neoplasms

,

,

unknown primary neoplasms

,

invasive hydatidiform mole

,

peripheral blood stem cell transplantation

,

urethral neoplasms

,

thyroid neoplasms

,

autoimmune diseases

,

polycythemia vera

,

severe combined immunodeficiency

,

pure red-cell aplasia

,

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

parkinson disease

,

,

biliary atresia

,

primary effusion lymphoma

,

neuroendocrine carcinoma

,

hemangiosarcoma

,

bone marrow transplantation

,

,

,

cholangiocarcinoma

,

anaplastic thyroid carcinoma

,

neuroendocrine tumors

,

hypertrophic pyloric stenosis

,

esophageal squamous cell carcinoma

,

renal insufficiency

,

hepatocellular carcinoma

,

reactive arthritis

,

b-cell leukemia

,

kidney transplantation

,

peritoneal neoplasms

,

,

mucinous cystadenocarcinoma

,

cystadenocarcinoma

,

dyskeratosis congenita

,

x-linked combined immunodeficiency diseases

,

desmoplastic small round cell tumor

,

thrombocytopenic purpura

,

,

neurofibrosarcoma

,

alzheimer disease

,

end stage liver disease

,

bronchiolitis obliterans syndrome

,

chronic granulomatous disease

,

neurotoxicity syndromes

,

,

human herpesvirus 8

,

lymphadenopathy

,

alveolar soft part sarcoma

,

,

malignant fibrous histiocytoma

,

large cell carcinoma

,

langerhans-cell histiocytosis

,

metabolic brain diseases inborn

,

branchio-oto-renal syndrome

,

homologous transplantation

,

non-gestational choriocarcinoma

,

smoldering multiple myeloma

,

nasopharyngeal carcinoma

,

epstein-barr virus infections

,

,

,

papillomaviridae

,

chronic obstructive pulmonary disease

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

carcinoid tumor

,

islet cell carcinoma

,

,

,

small cell carcinoma

,

,

,

,

immune system diseases

,

opportunistic infections

,

,

pulmonary hypertension

,

,

interstitial lung diseases

,

neutrophilic leukemia chronic

,

,

pathologic complete response

,

,

mast-cell leukemia

,

female genital diseases

,

urogenital neoplasms

,

endocrine system diseases

,

glandular and epithelial neoplasms

,

ovarian diseases

,

peritoneal diseases

,

uterine diseases

,

uterine cervical diseases

,

fallopian tube diseases

,

coronavirus infections

,

esophageal diseases

,

stiff-person syndrome

,

hemolytic anemia congenital

,

progressive multifocal leukoencephalopathy

,

neurofibromatosis 1

,

neurofibromatoses

,

nerve sheath neoplasms

,

,

gallbladder neoplasms

,

hemorrhagic stroke

,

nervous system diseases

,

urologic diseases

,

necrotizing enterocolitis

,

food intolerance

,

,

,

,

,

,

,

,

,

,

epidermolysis bullosa dystrophica

,

,

,

gastrointestinal diseases

,

,

,

,

,

gestational trophoblastic disease

,

trophoblastic neoplasms

,

,

wiskott-aldrich syndrome

,

graft rejection

,

nerve degeneration

,

urologic neoplasms

,

congenital bone marrow failure syndromes

,

alcoholic liver cirrhosis

,

adolescent development

,

hodgkin disease

,

large b-cell lymphoma diffuse

,

,

b-cell chronic lymphocytic leukemia

,

myeloproliferative disorders

,

mantle-cell lymphoma

,

bcr-abl positive chronic myelogenous leukemia

,

central nervous system neoplasms

,

follicular lymphoma

,

b-cell lymphoma

,

b-cell lymphoma marginal zone

,

large-cell lymphoma immunoblastic

,

,

nervous system neoplasms

,

myelodysplastic-myeloproliferative diseases

,

non-small-cell lung carcinoma

,

kidney neoplasms

,

healthy volunteers/patients

,

biphenotypic leukemia acute

,

primary myelofibrosis

,

neoplasm metastasis

,

brain neoplasms

,

urinary bladder neoplasms

,

head and neck neoplasms

,

waldenstrom macroglobulinemia

,

,

,

,

congenital abnormalities

,

rhabdomyosarcoma

,

refractory anemia with excess of blasts

,

neuroectodermal tumors

,

myelomonocytic leukemia acute

,

myeloid leukemia accelerated phase

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

monocytic leukemia acute

,

small cell lung carcinoma

,

myeloid leukemia chronic-phase

,

,

t-cell lymphoma cutaneous

,

erythroblastic leukemia acute

,

,

immunoglobulin light-chain amyloidosis

,

testicular neoplasms

,

,

,

megakaryoblastic leukemia acute

,

triple negative breast neoplasms

,

,

renal cell carcinoma

,

squamous cell carcinoma of head and neck

,

transitional cell carcinoma

,

sezary syndrome

,

mycosis fungoides

,

drug-related side effects and adverse reactions

,

,

sickle cell anemia

,

interdigitating dendritic cell sarcoma

,

,

male breast neoplasms

,

plasmablastic lymphoma

,

refractory anemia

,

endometrial neoplasms

,

,

liver cirrhosis

,

stomach neoplasms

,

cutaneous malignant melanoma

,

multiple sclerosis

,

t-cell leukemia

,

,

adenosquamous carcinoma

,

esophageal neoplasms

,

choroid plexus neoplasms

,

,

,

cardiomyopathies

,

hemoglobinopathies

,

classical conditioning

,

relapsing-remitting multiple sclerosis

,

inflammatory breast neoplasms

,

adult t-cell leukemia-lymphoma

,

phenylketonurias

,

pheochromocytoma

,

myocardial ischemia

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

diamond-blackfan anemia

,

,

amyotrophic lateral sclerosis

,

inferior wall myocardial infarction

,

acute-on-chronic liver failure

,

,

residual neoplasm

,

castration-resistant prostatic neoplasms

,

adenocarcinoma of lung

,

bronchiolo-alveolar adenocarcinoma

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

ganglioneuroblastoma

,

endodermal sinus tumor

,

induction chemotherapy

,

coronary disease

,

immunologic deficiency syndromes

,

radiation effects

,

,

st elevation myocardial infarction

,

,

,

choriocarcinoma

,

hypereosinophilic syndrome

,

,

critical illness

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

clear cell adenocarcinoma

,

acinar cell carcinoma

,

,

retinal neoplasms

,

radiation injuries

,

neuromyelitis optica

,

shwachman-diamond syndrome

,

basophilic leukemia acute

,

eosinophilic leukemia acute

,

,

anterior wall myocardial infarction

,

chagas cardiomyopathy

,

disease progression

,

chronic progressive multiple sclerosis

,

,

respiratory insufficiency

,

localized scleroderma

,

,

,

adrenal cortex neoplasms

,

adrenocortical carcinoma

,

,

progression-free survival

,

,

,

agammaglobulinemia

,

left ventricular dysfunction

,

angina pectoris

,

,

cross infection

,

sickle cell trait

,

autistic disorder

,

autism spectrum disorder

,

patient participation

,

,

,

myeloid leukemia acute

,

multiple myeloma

,

non-hodgkin lymphoma

,

myelodysplastic syndromes

,

breast neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

myeloid leukemia

,

,

plasma cell neoplasms

,

,

,

,

,

lymphoid leukemia

,

ovarian neoplasms

,

burkitt lymphoma

,

,

hematologic neoplasms

,

,

germ cell and embryonal neoplasms

,

,

chemotherapy-induced febrile neutropenia

,

graft vs host disease

,

myelomonocytic leukemia chronic

,

aplastic anemia

,

medulloblastoma

,

febrile neutropenia

,

ovarian epithelial carcinoma

,

prostatic neoplasms

,

,

hematopoietic stem cell transplantation

,

primitive neuroectodermal tumors

,

myelomonocytic leukemia juvenile

,

large-cell lymphoma anaplastic

,

,

systemic scleroderma

,

myocardial infarction

,

diffuse scleroderma

,

uterine cervical neoplasms

,

alcoholic hepatitis

,

,

,

autologous transplantation

,

hematopoietic stem cell mobilization

,

,

female infertility

,

,

alcoholic liver diseases

,

,

premature birth

,

primary ovarian insufficiency

,

diabetes mellitus

,

mediastinal neoplasms

,

female genital neoplasms

,

stevens-johnson syndrome

,

,

,

,

,

,

,

,

,

neonatal sepsis

,

habitual abortion

,

adjuvant chemotherapy

,

animal mammary neoplasms

,

,

arterial occlusive diseases

,

hemophagocytic lymphohistiocytosis

,

thrombocytopenic purpura idiopathic

,

diabetic neuropathies

,

,

intermittent claudication

,

abnormal karyotype

,

lupus nephritis

,

,

chediak-higashi syndrome

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

churg-strauss syndrome

,

hypersensitivity

,

polyarteritis nodosa

,

granulomatosis with polyangiitis

,

takayasu arteritis

,

leukocytoclastic vasculitis cutaneous

,

aortic arch syndromes

,

tissue adhesions

,

glycogen storage disease type ii

,

,

,

autonomic nervous system diseases

,

primary dysautonomias

,

hypoventilation

,

neurodegenerative diseases

,

chromosome aberrations

,

acute liver failure

,

,

,

brain hypoxia-ischemia

,

hypoplastic anemia congenital

,

antiphospholipid syndrome

,

graft vs leukemia effect

,

,

,

chemoradiotherapy

,

sleep initiation and maintenance disorders

,

,

Calcium dobesilate

postoperative nausea and vomiting

,

immunoglobulin light-chain amyloidosis

,

smoldering multiple myeloma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

myelodysplastic syndromes

,

myelomonocytic leukemia chronic

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

liver neoplasms

,

,

non-small-cell lung carcinoma

,

non-hodgkin lymphoma

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

cerebrotendinous xanthomatosis

,

,

,

myeloid leukemia acute

,

deficiency diseases

,

paraproteinemias

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

breast neoplasms

,

immune system diseases

,

hematologic neoplasms

,

type 2 diabetes mellitus

,

,

metabolic diseases

,

,

glycogen storage disease

,

,

immunoglobulin g4-related disease

,

,

myeloid leukemia

,

,

falciparum malaria

,

,

,

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

renal insufficiency

,

hematologic diseases

,

blood protein disorders

,

neoplasms by histologic type

,

prostatic neoplasms

,

circulating neoplastic cells

,

x-linked bulbo-spinal atrophy

,

heart transplantation

,

non-small-cell lung carcinoma

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

esophageal neoplasms

,

,

neoplasm metastasis

,

aplastic anemia

,

multiple myeloma

,

plasma cell neoplasms

,

hypercholesterolemia

,

meningococcal infections

,

hemolytic anemia autoimmune

,

,

meningococcal meningitis

,

stomach neoplasms

,

,

kidney diseases

,

gaucher disease

,

smoldering multiple myeloma

,

,

chronic renal insufficiency

,

hyperphosphatemia

,

multiple sclerosis

,

,

homozygous familial hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

healthy volunteers/patients

,

,

glycogen storage disease type ii

,

atopic dermatitis

,

diabetes mellitus

,

insulin resistance

,

,

glycogen storage disease type iii

,

,

non-hodgkin lymphoma

,

,

postmenopausal osteoporosis

,

,

lymphoproliferative disorders

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